Overexpression mirna
WebMiR-199a-5p overexpression determines lower levels of the glycolytic intermediate G6P and adenosine triphosphate (ATP). Due to the strict dependence of cancer cells from aerobic glycolysis, miR-199a-5p-mediated interference with this metabolic phenotype leads to impairment of cell proliferation in vitro and tumorigenic properties in vivo. WebApr 14, 2024 · COL2A1 expression decreased upon miRNA-326 overexpression (Figure 8C,D). Collectively, these data suggest that miRNA-326 can promote chondrocyte …
Overexpression mirna
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WebThe aim of the present study was to explain the mechanism of miR-30a-3p overexpression in sepsis-induced cell apoptosis in vitro and in vivo.For the in vitro cell experiments, H9c2 … WebMar 1, 2013 · Powerful in vivo experiments showed that ectopic overexpression of miR-199a-3p and miR-590-3p exerts beneficial effects on the mouse myocardium following infarction. Overexpression of either miRNA by viral delivery in the peri-infarcted region induced a reduction in infarct size that resulted in improved function and reduced …
WebJan 31, 2024 · Overexpression of microRNA-19a in NSCLC A549 and H1299 cell lines promoted proliferative and migratory abilities. Overexpression of miR-19a enhanced the proliferation and migration of airway smooth muscle (ASM) cells, whereas inhibition of miR-19a decreased the proliferation and migration of ASM cells. WebDec 1, 2016 · Overexpression of miRNA-21 in vivo was conducted by means of intrathecal injection of lentivirus vectors containing pre-miRNA-21. The vehicle or control lentivirus vectors were given to the control group and the control vector group, respectively. Five days later, spinal cord ischemia was accomplished in rats by crossclamping the descending ...
WebBackground: Hepatocellular carcinoma (HCC) is a very common neoplasm worldwide, and competitive endogenous RNA (ceRNA) plays an important role in the development of … WebCells were infected with LINC00461 overexpression, miR-411-5p overexpression, or corresponding knockdown, lentiviral particles. After 2–3 days, levels of green fluorescent protein in the cells were observed under a fluorescence microscope (a fluorescence rate of 50–80% was expected).
WebMar 2, 2024 · In colorectal cancer, the mechanisms underlying tumor aggressiveness require further elucidation. Taking advantage of a large panel of human metastatic colorectal cancer xenografts and matched stem-like cell cultures (m-colospheres), here we show that the overexpression of microRNA 483-3p (miRNA-483-3p; also known as MIR-483-3p), …
WebJun 1, 2024 · Overexpression of miR-210 contributed to aberrant inflammatory cytokine expression in CD4 + T cells . Nevertheless, the role of miR-210 overexpression, the regulatory mechanisms, and in vivo physiological significance in the development of psoriasis remain poorly understood. quick fit doncaster balby roadWebOct 1, 2014 · Although lentivirus-mediated miRNA overexpression is a frequently applied method in basic research Mayoral and Monticelli, 2010; Zollner et al., 2014), no miRNA overexpression has been reported so ... ship\u0027s complementship\\u0027s constantWebSep 26, 2024 · Specific miRNA overexpression did not elicit any characteristic apoptotic changes (Figure 5b,c). FIGURE 4. Open in figure viewer PowerPoint. Effects of miR-9/9* and/or miR-124 overexpression on cellular proliferation in the developing retina. (a) Immunostained retinal sections at P3. quickfit gatesheadWebJun 19, 2024 · Moreover, overexpression of miR-98 also led to increased apoptosis in LX-2 cells (Figure 2F). Furthermore, forced miR-98 expression significantly inhibited the migration capability of LX-2 cells (Figures 2G,H). Our results revealed that overexpression of miR-98 could inhibit the activation and proliferation of HSCs. ship\\u0027s company the entire collectionWebMature microRNAs (miRNAs) are a class of naturally occurring, small non-coding RNA molecules, about 21-25 nucleotides in length. MicroRNAs are partially complementary to one or more messenger RNA (mRNA) molecules, and their main function is to downregulate gene expression in a variety of manners, including translational repression, mRNA … ship\\u0027s complement crosswordWebJul 21, 2013 · Overexpression of a microRNA in rice increases yield, suggesting new routes to crop improvement. Increasing grain yields is a major focus of crop breeders around the world. Here we report that ... ship\\u0027s complement